Can I modify chrome_settings_overrides in manifest.json at runtime?

I want to create addon for set default homepage & default search engine.

And I found this., Everything done with manifest.json

But I want to change default homepage and search engine url via addon setting.
eg. // x and y get from setting page.

Which APIs can I use?

The same, just set it to an URL in your extension and have your extension redirect to the actual target.

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Thanks for your smart solution. It works.